Targeting cancer with Click Chemistry

Less than 1% of administered drugs make it to their desired location in the body.

Let's do better

Next generation tumor-targeting

Our proprietary Click Activated Protodrugs Against Cancer (CAPAC^®) platform is a pre-targeting approach, capturing payloads at the tumor via in-vivo click chemistry, a 2022 Nobel Prize-winning technology.

We are the first company to use click chemistry in patients.

CAPAC is modular

CAPAC separates the binder from the payload and reunites them at the tumor.

Clickable binder

Binds selectively to the tumor

Clickable payload

Either a radioisotope or cancer drug that is inert until it clicks with the binder at the tumor

Activation

When the systemically administered clickable payload reaches the clickable binder at the tumor, a click chemistry reaction takes place. For radioisotopes, this locks the radioisotope at the tumor; for chemotherapy this activates the payload.

Changing what's possible

We separate tumor targeting from the payload, and rely on chemistry, not biology, for activation. This leads to maximum active payload at the tumor and lower systemic toxicity than has been previously possible.

CAPAC is designed to expand the scope of potential targets and widen the therapeutic window of antibody drug conjugates (ADCs) and targeted radiopharm approaches. CAPAC has been validated in the clinic and we are rapidly advancing novel therapies for patients with limited effective treatment options.

Latest News

conference

Shasqi presented 2 posters at the 2025 AACR Annual Meeting

Pre-targeting with in vivo click chemistry enables preferential drug exposure in tumors versus normal tissues

View presented poster here

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First-in-class Click Chemistry-Based Pre-Targeting of CEACAM5 Tumor Antigen Selectively Activates an MMAE Payload at Tumors

View the presented poster here

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conference

Shasqi presented poster at the 15th World ADC London

media

Tackling ADCs 1% problem

2025 - AACR

conference

Shasqi presented 2 posters at the 2025 American Association for Cancer Research (AACR) Annual Meeting

Together we can transform cancer treatment

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